The National Institute of Health (NIH)-Global Alliance for Chronic Diseases (GACD) funding opportunity supports applications that propose implementation research to reduce the risks of NCDs in the context of cities in low- and middle-income countries (LMICs) and among American Indian/Alaska Native (AI/AN) populations in US cities, with the potential to equip policymakers and practitioners with evidence-based strategies for prevention and/or management of NCDs among disadvantaged populations globally.